In the year 2138, virtual reality gaming is booming. Yggdrasil, a popular online game is quietly shut down one day. However, one player named Momonga decides to not log out. Momonga is then transformed into the image of a skeleton as "the most powerful wizard." The world continues to change, with non-player characters (NPCs) beginning to feel emotion. Having no parents, friends, or place in society, this ordinary young man Momonga then strives to take over the new world the game has become.

In the year 199X, human civilization has been all but destroyed by a nuclear holocaust. In an age where the strong rule over the weak, the survivors of the fallout struggle over the remaining supply food and water left. Kenshiro, successor to an ancient, deadly martial art known as Hokuto Shinken (Fist of the North Star), wanders the wasteland with seven scars in the shape of the Big Dipper on his chest. This infamous style uses the body's hidden 708 pressure points to destroy opponents from within and allows practitioners to unleash 100% of their humanly strength. Accompanied by a young thief and an orphan girl, this messiah brings justice to this lawless world with the strongest fist in the world.

Grimm's Fairy Tale Classics is a Japanese animated anthology series by Nippon Animation. The episodes are adaptations of a variety of folk and fairy tales, and not limited to Grimm's Fairy Tales.